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Although liver transplantation offers a curative approach for B6 non-respondents, it carries notable challenges, including surgical risks, the need for prolonged immunosuppression and limited donor availability

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Methionine is then converted into S-adenosylmethionine (SAM), which donates methyl groups in reactions catalyzed by methyltransferases, including DNA methylation, producing S-adenosylhomocysteine (SAH) that is converted back into homocysteine